Three researchers William G Kaelin, Sir Peter Ratcliffe and Gregg L Semenza have been awarded the Nobel Prize for medicine (2019) on Monday for their work on how cells adapt to oxygen availability. Nobel Assembly held that their discoveries on how cells sense and adapt to oxygen availability would pave way for new cancer treatments. Assembly’s Randall Johnson commenting on the works of the trio informed that they had found the molecular switch that regulates how human cells adapt when oxygen levels drop. (It is pertinent to add here that all animal cells use oxygen to convert food into usable energy.)Nobel Prize Jury maintained: “They established the basis for our understanding of how oxygen levels affect cellular metabolism and physiological function…their research has paved the way for promising new strategies to fight anaemia, cancer and many other diseases. Intense ongoing efforts in academic laboratories and pharmaceutical companies are now focused on developing drugs that can interfere with different disease states by either activating, or blocking, the oxygen-sensing machinery.”
The cash award of Rs. 833,000 Euros will be shared by the trio: 61-year-old Kaelin who works at the Howard Hughes Medical Institute in the US; 63-year-old Semenza who discharges his duties as director of the Vascular Research Program at the John Hopkins Institute for Cell Engineering; and 65-year-old Ratcliffe who is director of clinical research at the Francis Crick Institute in London, and director of the Target Discovery Institute in Oxford.
Kaelin speaking about receiving the phone call in the morning said: “I was aware as a scientist that if you get a phone call at 5am with too many digits, it’s sometimes very good news, and my heart started racing. It was all a bit surreal.”
A relevant piece published earlier:
Japanese researcher Yoshinori Ohsumi gets 2016 Nobel Prize in medicine!
TOKYO: Japanese cell biologist Yoshinori Ohsumi has been honored with the 2016 Nobel Prize in Medicine for his inventions and findings of mechanisms for autophagy on Monday.
Since the earliest Nobel Prizes were given in 1905, it was the 107th reward in the Medicine category.
According to the details, in 2016 some 273 investigators from all across the globe have been nominated for the Nobel Prize in Physiology or Medicine.
From tumor to Parkinson’s sickness, Ohsumi’s discovery apropos autophagy (how the body collapses and recovers cellular components) chips-in towards enlightening what goes off beam in an assortment of syndromes.
It is worth mentioning here that the Karolinska Institute awarded Ohsumi for brilliant experiments in the 1990s on autophagy, the vitae by means of which cells reprocess their content.
Three investigators who discovered cures for malaria and other tropical ailments were bestowed in 2015.
PHYSICS: Royal Swedish Academy of Sciences after much deliberation has announced that one half of this year’s Nobel Physics Prize will go to David J. Thouless (University of Washington, Seattle, WA, USA) and the remaining half will be shared by F. Duncan M. Haldane (Princeton University, NJ, USA) and J. Michael Kosterlitz (Brown University, Providence, RI, USA).
Laureate in Chemistry will be announced on Wednesday, Nobel Peace Prize on Friday. Whereas, the economics and literature winners will be announced in the next week.
Each winner will also take US $ 930,000 home.