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Researchers have identified 10 new cancer risk genes

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10 new cancer risk genes

ISLAMABAD: Using publicly available data, researchers have identified 10 new genes that are predisposed to cancer among others, an advance that would contribute to improving cancer diagnoses and prevention in the future.

There are many genetic causes of cancer. While some mutations are inherited from parents, others are acquired all throughout life due to external factors or due to mistakes in copying DNA. In the study, published in Nature Communications, a team of researchers developed a new statistical method named ALFRED and identified 13 candidate cancer predisposition genes, of which 10 are new from tumour sequencing data.

“We applied our method to the genome sequences of more than 10,000 cancer patients with 30 different tumour types and identified known and new possible cancer predisposition genes that have the potential to contribute substantially to cancer risk,” said principal investigator Ben Lehner, ICREA – Catalan Institution for Research and Advanced Studies in Spain. “Our computational method uses an old idea that cancer genes often require ‘two hits’ before they cause cancer.

We developed a method that allows us to systematically identify these genes from existing cancer genome datasets,” said Solip Park, from the Centre for Genomic Regulation (CRG) – a Barcelona-based research facility. For the study, the team combined data from many different projects and by applying a new computational method, were able to identify important cancer genes that were not identified by the original studies.

Relevant pieces published earlier: 

i) According to a new report on cancer treatments that attack tumors based on their individual genetic traits – not their location in the body – far outperform traditional methods, extending survival for twice as many patients. The precision medicine field of targeted therapy involves testing tumors for clues about their genetic mutations, and matching patients with new drugs designed to block cancer’s growth on a molecular level. Researchers in Texas began studying the impact of these therapies in 2007, after seeing the success of Gleevec (imatinib) – a breakthrough drug approved by US regulators in 2001 that showed huge success against chronic myeloid leukemia. The results of the first and largest precision medicine trial to look at survival across a host of cancer types and many different targeted therapies were released at the American Society of Clinical Oncology meeting in Chicago, the world’s largest annual cancer meeting. The study, called IMPACT, enrolled 3,743 patients at Texas MD Anderson Cancer Center from 2007 to 2013. All the patients had advanced cancers, or “end-stage disease,” involving cancers of the gastrointestinal tract, breast, or lung. Melanoma and cancer of the female reproductive tract were also included, along with more rare types of cancer. Those enrolled had typically tried at least four – and sometimes up to 16 – other treatments that failed to halt the growth of their cancer. Patients who received molecularly targeted therapies either got an investigational drug then being tested in a clinical trial or an FDA-approved targeted therapy commercially approved for another indication.

ii)  Consumption of broccoli has long been linked to innumerable health boons. Considering this, savants have further claimed that it could fend off Type 2 Diabetes (T2D). As per their findings, ingesting its extracts could potentially assist people suffering from T2D to control over their blood sugar levels. This magical veggie is stuffed with vitamins, fiber, and disease-combating phytochemicals, which may help overturn the disease symptoms. So as to prove this, scholars have given concentrated broccoli sprout extracts to some 97 participants with T2D for around 12 weeks. Their findings demonstrated that those, who had dysregulated disease, have been reported with considerably reduced fasting blood glucose levels and glycated hemoglobin (HbA1c) when compared to others. Apart from this, a couple of previous researches have shown that broccoli has the potential to decrease cholesterol levels. Also, its daily consumption might make your bones stronger, detoxify your body and maintain the digestive system and vision. Not to mention that broccoli could oust the expansion of lethal cancer cells. According to the statistics, around 450 million folks come up in T2D across the globe. Regrettably, more than 15 percent of those patients cannot receive the first-line cure metformin due to kidney damage hazards. Journal Science Translational Medicine has published their ramifications. (23rd of June, 201

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People with type 2 diabetes may be testing blood sugar too much

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women diabetes

MICHIGAN: People with type 2 diabetes might be testing their blood sugar levels too much, a study says.
Researchers at the University of Michigan say that roughly 14 percent of people with diabetes, but who don’t require insulin, are spending hundreds of dollars per year and using thousands of test strips to check something that is not necessary. New research published Monday in JAMA Internal Medicine, based on insurance information for more than 370,000 people with Type 2 diabetes but who did not take insulin, suggests that these tests are unnecessary.
One of my patients who didn’t need to be testing daily told me that her previous doctor had told her to test her sugars two or three times a day, Kevin Platt, the internal medicine resident in the Department of Internal Medicine at University of Michigan and study lead investigator, said in a press release. These data show that over-testing is quite common – and with the appropriate guidance can be reduced significantly.
About 23 percent of people in the study refilled prescriptions for test strips at least three times a year, getting 90 strips at a time. Another 43 percent of participants filled prescriptions exclusively for metformin or other medicines that don’t have a risk of hypoglycemia. Once patients established the proper dosage of medication that didn’t cause a blood sugar spike, they no longer needed daily testing.
But those two groups kept testing their blood sugar, even though they didn’t need to. The researchers say many patients needlessly test daily to see how well exercise, dieting, and their medication regimens are actually working.

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Over 400 dengue cases reported in 2018!

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RAWALPINDI: District Health Officer Dr. Zeeshan Ahmed today said around 421 dengue positive patients were reported in Allied hospitals of the city in 2018, while last year 334 patients results were positive, in 2016 the number was  1106 and in 2015 the number was 3303.
He said to date, the allied hospitals have registered 421 confirm patients while at present only 5 dengue patients were under treatment in hospitals. The DHO said that Municipal Corporation area and Potahar Town witnessed a sharp decrease this year in dengue patients as 63 cases were reported in MCR area and 82 in Potohar area while last year the number was 74 in MCR and 189 in Potohar Town.
While Rawalpindi Cantonment Board area has witnessed an increase this year as 197 cases were reported and the number was only 40 last year, he added. He said that in the RCB area the number of cases were increased as there were some hurdles to reach sensitive areas. “Dengue fever situation is under control and no death has occurred due to it,” he added.

 

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E-cigarette makers using aggressive marketing tactics

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E-cigarette makers using aggressive marketing tactics

SEOUL: Makers of e-cigarettes are employing an active marketing strategy, reaching out directly to consumers, industry officials said today.
KT&G, Philip Morris Korea and British American Tobacco (BAT) Korea have all set up departments to exclusively promote sales of their e-cigarettes and are increasing the number of their street stores.
Philip Morris was the first of the pack, opening a shop in June last year with the launch of its IQOS. It has since launched four more independent stores nationwide and has a sales booth at 20 Electro Mart outlets, an electronics store chain run by Shinsegae Group.
The company now runs two call centers, one each in Seoul and in the southeastern city of Busan, and has increased staff from 35 to 170 for around-the-clock operation.
KT&G has three stores, including a standalone in southern Seoul and two shop-in-shop flagships. It offers a visiting service to customers to handle their requests and has 200 staff members standing by.
The company has 10 after-sales service centers throughout the country and 31 smaller consultation stations to solve simple product problems. It has added incentives by giving leather cases to purchasers of its product line.
BAT Korea allows online purchases of its e-cigarette product Glo after confirming the age and identity of the buyer. In addition to its recently opened flagship store, it set up Glo care zones at a number of Seven-Eleven convenience stores that can handle after-sales service care and free product experience.
Industry officials say another change in their marketing tactic is the use of media events when new products are launched.
Such aggressive marketing has displeased social commentators who see it as contradicting efforts to bring down the country’s smoking rates. These watchers also want the government to amend laws on the tobacco industry that are outdated and unable to regulate the new e-cigarette market.
“With the launch of e-cigarettes, the industry can no longer survive in the old way,” an industry official said. “We need to communicate more actively with different segments of society to adapt better to the changing market conditions and to improve the regulations on tobacco.”

 

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